3 Oxford Univeristy Clinical Research Unit, Indonesia
Also, the beneficial effect of exercise on muscle mass is known to help in the management of insulin resistance, which is a prediabetes state, thus preventing type 2 diabetes by having the so-called browning effect of white adipose tissue and effect on cellular energetics through mitochondrial biogenesis (Weyh et al., 2020)
Pierno S, Camerino GM, Cannone M, Liantonio A, De Bellis M, Digennaro C, Gramegna G, De Luca A, Germinario E, Danieli-Betto D, Betto R, Dobrowolny G, Rizzuto E, Musaro A, Desaphy JF, Camerino DC (2014) Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice
The strategy of covalently conjugating metal-based anticancer agents to amphiphilic polymers, that could self-assemble into nanoparticles, could present a method for the tumor-selective anticancer therapy
doi:10.1038/jhg.2010.53