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Metformin has been demonstrated to prevent renal tubulointerstitial fibrosis (181) by addressing the reduced energy supply resulting from impaired fatty acid oxidation (FAO) in proximal tubular cells

Continued research is vital for developing regulatory standards and protective strategies, especially for vulnerable populations such as pregnant women and young children

HIF-1 and HIF-2: Synergistic regulation of glioblastoma Malignant progression during hypoxia and apparent chemosensitization in response to hyperbaric oxygen

Its core function lies in the degradation of extracellular matrix (ECM) proteins, especially type IV collagen in the basement membrane

Cell viability assays Adherent cell viability was determined either by Crystal violet staining or by neutral red staining in 96-well plates 66