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Safety signals in RCTs are generally acceptable, but adverse-event capture and classification remain suboptimal

Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study

Most side effects are reversible upon discontinuation of therapy, but serious reactions necessitate prompt evaluation and supportive care

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