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Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies

The establishment and preservation of the BBB are intricate cooperative processes, hinging on the synergistic actions among the constituent cells of the neurovascular unit (NVU)endothelial cells (ECs), pericytes, astrocytes, extracellular matrix, and neurons (Fig