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Further, the frequent melanogenic antigen-positive CD8 + T cells in the blood of vitiligo patients correlate with disease severity [41,42]

Specifically, it stimulates melanocortin receptors, mainly MC3R and MC4R, in the central nervous system

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Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight control, and energy expenditure