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At a high level (Figure 3), soluble fibrinogen, typically as a 5 45 nm complex of three different polypeptides ( 2 2 2 ) (MW ~ 340 kDa) [81] plus internal fibrinopeptides A and B, and one of the most abundant proteins in plasma (present at typically 24 gL 1 [82,83]), is acted upon by the serine protease thrombin

These factors regulate the expression of various target genes to orchestrate cellular adaptation to hypoxic conditions