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Supplemental Table S7 ), revealing the upper limit for tolerable Fe 2+ fraction being about 0.3 of the total iron ( Figure 4D )

In vitro and in vivo studies have shown that genetic and pharmacological inhibition of USP14 induces degradation of an androgen receptor (AR), favoring tumor suppression in AR-positive breast cancer cells or prostate cancer cells (Liao et al., 2017