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Zhang SJ, Li YF, Wang GE, Tan RR, Tsoi B, Mao GW et al (2015) Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway

H., Tan, E

In addition to mitochondrial ROS from Complexes I, II, and III, enzymes, such as the -ketoglutarate dehydrogenase (KGDHC) and pyruvate dehydrogenase (PDC) complexes, involved in mitochondrial metabolism also produce ROS through forward electron transfer, and both act as important sources of ROS in the mitochondria (8587) ( Figure 1 )

In cases where NAC is administered orally, the typical dosing regimen is a loading dose of 140 mg/kg, subsequently followed by 70 mg/kg every 4 h until 18 doses are administered[60,68]