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Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway

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Given that gluten peptides are rich in Pro residues too, a dual enzyme therapy combining EP-B2 and prolyl endopeptidase (PEP) has been developed to target both AAs

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