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Lin PY, Lyu HC, Hsu CY, Chang CS, Kao FJ

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Major cyclic regulator of melatonin generation in pineal gland is prevailing light/dark environment (1-3), activating the anterior hypothalamus via the axons of retinal ganglion cells running in the optic nerves and forming retino-hypothalamic tract to reach the SCN that are connected with pineal gland through paraventricular nuclei, preganglionic sympathetic neurons, innervating superior cervical ganglia and then postsynaptic sympathetic neurons supplying pineal gland ( Fig

Doing so will help the serum to penetrate deeper into the inner skin layer more efficiently

Area under the curve (AUC) : Total exposure over time, measured as AUC, typically favors injectable delivery by 2-4x when comparing equivalent doses