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doi: 10.1016/j.jtha.2023.04.039 125 ChunHICoutavasEPineABLeeAIYuVLShallowMKet al

B12 is water-soluble, with excess typically excreted

For 78c, the most important interaction in the active site appears to be a hydrophobic interaction of C4 group and Trp176 and the hydrogen bond between the 2-ketoresidue and the side chain amide of Asp183 [78]