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These two major pathological hallmarks contribute to changes in numerous cellular and subcellular events, such as mitochondrial dysfunction, redox imbalance, and neuroinflammation that lead to activation of neurotoxic cascade towards cell death, thereby impairing synaptic communication [81,82]

used a single antiMHC I antibody, a large fraction of which will bind already in the skin and lymphatic vessels to MHC I expressed at high levels on all nucleated cells, which possibly hampered its detectability in the microscopic studies of the LN parenchyma

Different tool, different use case

D1 catalyzes the ORD and/or IRD of a variety of iodothyronine derivatives, although it is most effective in catalyzing the ORD of rT3, while the IRD of both T4 and T3 is strongly facilitated by sulfation of these iodothyronines (17)

Reduced growth and early senescence were observed in antisense potato plants underexpressing a GMP gene, in parallel with lower AsA content (-60%) and cell wall-associated mannose (-70%) in leaves, while tubers develop normally ( Arabidopsis vtc1 mutant, defective in GMP activity (Veljovic-Jovanovic et al., 2001)