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With regard to the amelioration of hyperglycemia in fat-transplanted Insr P1195L/ +/HFD mice, it is unclear whether the improved glucose uptake into the transplant may play a major role, as WAT has been reported to play a minor role in glucose uptake in rodents 20

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As shown in Table 1 and Figure 6, such inhibitors mainly include MvH45 (Van Haren et al., 2017), AK-12 (Ruf et al., 2022), MS2756 (Babault et al., 2018), MS2734 (Babault et al., 2018), GYZ-78 (Gao et al., 2019), NS1 (Kuzmi et al., 2021), LL320 (Chen D

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