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1) to the nucleus, and nuclear trafficking of most proteins is controlled by the small GTPase, Ran [7]

10.1016/j.cgh.2013.09.047 131 NaA

While pharmaceutical companies are careful to run trials under optimal conditions (for example, restricting patients to those most likely to benefit, only including patients that can be treated soon after onset when necessary, and ensuring accurate dosing), not all N-acetylcysteine trials represent the optimal conditions for efficacy