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In summary, this work provides an elegant mechanistic investigation to support the formation of two homodimer metabolites identified in the bile and feces from a 14 C rat ADME study, and further exemplifies the diversity of P450 enzymes in producing unexpected and novel metabolites (Guengerich and Munro Citation2013)

Curr Atheroscler Rep 21 , 27 (2019)

Intestinal microorganisms metabolize TML into trimethyl-5-aminovaleric acid (TMAVA), which can competitively inhibit the binding of -BB to BBD, thereby inhibiting carnitine biosynthesis and FAO in the liver, promoting steatosis and aggravating fatty liver [250]

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