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Preclinical studies have laid a foundation for understanding its regulatory potential, but the translational gap exposed by GDNF/NRTN clinical trials underscores the need for humility in assessing its clinical value

Acknowledgments We thank Figdraw ( for expert assistance in the pattern drawing

This approach not only induces cuproptosis but also increases PD-L1 expression, transforming cold tumors into hot tumors that respond to immunotherapy, significantly inhibiting tumor growth and activating a systemic anti-tumor immune response

[DOI] [PubMed] [Google Scholar] 698.Taylor A, et al

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