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In general, gene mutations with large biological effects (i.e., optic neuropathy) are rare whereas gene variants associated with smaller effects are common (12) (see below)

Comparative effects of tocotrienol-rich fraction, -tocopherol and -tocopheryl acetate on inflammatory mediators and nuclear factor kappa B expression in mouse peritoneal macrophages

Low serum selenium and total carotenoids predict mortality among older women living in the community: the womens health and aging studies

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors