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The SASP includes cytokines, chemokines, growth factors, and extracellular matrix-degrading enzymes, which promote local inflammation and tissue degeneration.23 Tissue Dysfunction: Senescent cells accumulate in various tissues as organisms age, including the skin, skeletal muscle, adipose tissue, liver, and vasculature

Correcting low-grade systemic metabolic acidosis with alkali salts, such as sodium bicarbonate or potassium citrate, corrects some of these biochemical consequences (Hazard 1982

Trypsin was set as the digestion enzyme

Nevertheless, while animals represent a tool to study NAFLD and NASH, it is unlikely that any single animal model will reflect all aspects of human NASH and researchers must critically select the model(s) best suited for the subject of investigation

The metallic NPs were shelled with mSiO 2 via sonication, and the functionalization of stalks was carried out by the chemical method