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Multiple Mechanisms of Dimethyl Fumarate in Amyloid -induced Neurotoxicity in Human Neuronal Cells

[DOI] [PubMed] [Google Scholar] 8.Dalile B., Van Oudenhove L., Vervliet B., Verbeke K

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For instance, methylation abnormalities observed in brain tissue from certain ID patients are linked to atypical splicing of neurodevelopment-related genes, indicating that early epigenetic changes may critically influence later neurodevelopmental stages (Niggl et al., 2023)

In order to develop novel epimetabolic combination therapies, future research should concentrate on clarifying the metabolic-epigenetic-immune regulatory network and exploring the impact of metabolites like -KG and NAD+ on the epigenetic reprogramming of T cells