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Additionally, c-Myc can transcriptionally upregulate the expression of the cystine/glutamate antiporter SLC7A11, facilitating the export of intracellular glutamate from the cell while promoting the uptake of extracellular cystine

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This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration

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