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Of note, evidence also support that when applied with high dose, such as 100 mg/kg/d, quercetin did not show significant improvement in renal function or protection against doxorubicin-induced renal injury ( Oral pretreatment of quercetin in rats with gentamicin-induced renal injury (50 mg/kg) for 10 days revealed an improvement in renal injury

This can lead to an uneven concentration in the vial, which compromises its reliability for consistent dosing.

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