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Furthermore, I148M oe macrophages had an impaired mitochondrial electron transport chain (ETC) system as reflected by significantly reduced cofactors, FAD and NAD metabolites, as well as genes linked to the ETC complexes, MT-ND1, MT-SHDA, MT-CYTB, MT-CO1, MT-CO2, and ATP6 in both MASH patients and macrophages carrying the PNPLA3 I148M variants, accompanied by reduced mitochondrial ROS production (-15%)

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However, her own health challenges led her to pursue a career in Nutritional Therapy