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Melanotan-1's selectivity for MC1R eliminates most of those off-target effects, which is why clinical trials reported adverse event rates of 812% for nausea with Melanotan-1 versus 3550% for nausea, flushing, and spontaneous erections with MT2

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Cancers (Basel) 10(2):29 Genazzani AD, Lanzoni C, Ricchieri F, Santagni S, Rattighieri E, Chierchia E, Monteleone P, Jasonni VM (2011) Acetyl-LC in hypothalamic amenorrhea