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TGF signalling in control of T-cell-mediated self-reactivity

As more of these units are assembled within a single construct, questions of complexity and feasibility naturally move to the foreground

It is constantly used by our body cells to keep them functioning properly and protect them from damage due to free radicals

Abbreviations AA: Alopecia Areata NAC: N -acetylcysteine System XC: Cystineglutamate transporter exchange transport system EAAT3: Excitatory amino acid transporter 3 ASCT: Alanineserinecysteine transporter GSH: Glutathione Hcy: Homocysteine CBS: Cystathionine--synthase CSE: Cystathionine--lyase GGT: -Glutamyl transpeptidase ROS: Reactive oxygen species MT: Metallothionein Nrf2: Nuclear factor erythroid 2-related factor 2 PTEN: Phosphate and tensin homolog deleted on chromosome 10 PTP: Protein tyrosine phosphatase CoA: Genome-wide association studies CoA: Coenzyme A TCA: Tricarboxylic acid TRP-1: Tyrosinase-related protein 1 TRP-2: Tyrosinase-related protein 2 GPX4: GSH peroxidase 4 mTORC1: Mechanistic target of rapamycin complex 1 Rag: Recombination activating gene 4EBPs: Eukaryotic initiation factor 4E-binding proteins -glucys: Amino-acid transporter solute carrier family 7 member 11(SLC7A11) -glutamatecysteine INF-: Interferon HHcy: Hyperhomocysteinemia CRH: Corticotropinreleasing hormone References Alsenaid A et al (2023) Trichoscopy pattern and evaluation of serum vitamin D status in alopecia areata

Ernhrung: Physiologische Grundlagen, Prvention, Therapie, 2