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Description

Tyacke, R

Schaefer, P

Short-term priorities: biomarkers of organelle-level zinc dyshomeostasis A major limitation in current clinical practice is that circulating zinc concentrations provide little insight into intracellular zinc distribution or the functional state of zinc-dependent organelles

The GCL enzyme is a heterodimer formed by two subunits: the heavy subunit or glutamate cysteine ligase catalytic subunit (GCLC, 73 kDa) and the light subunit or glutamate cysteine ligase modulating subunit (GCLM, 30 kDa)

The intense inflammatory reaction to this airway infection consists of chemokine and cytokine expression (IL-8 and tumor necrosis factor (TNF)) and mucin secretion 12 , as well as PMN accumulation 13 and the associated release of serine proteases 14, 15 , which are themselves proinflammatory stimulants 16, 17