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doi: 10.1016/j.neulet.2015.05.019 90 MenkeANitschkeFHellmuthAHelmelJWurstCStonawskiSet al

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For patients on hydrocodone bitartrate and acetaminophen tablets who are physically opioid-dependent, initiate the taper by a small enough increment (e.g., no greater than 10% to 25% of the total daily dose) to avoid withdrawal symptoms, and proceed with dose-lowering at an interval of every 2 to 4 weeks

For more details, see reference ( The final section will focus on the MM environment, with particular attention to the bone marrow (BM) niche, aiming to identify new players and leverage their unique properties to enhance tumor eradication