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Epidemiological evidence shows that a high dietary copper intake is associated with a reduced incidence of coronary heart disease [39]

Radical scavengers play a critical role by reacting with and neutralizing peroxide radicals, thereby halting the chain reactions of peroxidation and enhancing the quality and shelf life of food products (Soares et al

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The flavone with the greatest ability to reduce free radicals and inflammation mediators is baicalein

Prior art literature such as United States Patents US4797284 and US4880633 had employed propylene glycol as a penetration enhancer which is gelled with 2 percent hydroxypropyl guar (HP-60 Jaguar from Celanese) which served as a dissolved drug reservoir