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10.1038/nm.2538 165 WeilandA.WangY.WuW.LanX.HanX.LiQ.et al (2019)

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* Food Supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle

That said, mild effects can occur in some people, especially when starting any new supplement: Temporary bloating or fullness (more common with collagen) Mild digestive discomfort if taken without enough water These are usually short-lived and can be reduced by: Taking supplements with adequate water Starting with recommended doses Choosing high-quality, well-absorbed formulations Using clinically formulated products from trusted brands helps minimize unnecessary reactions