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Together, excessive and reduced production of neuro-toxic and -protective kynurenines, respectively, may exacerbate excitotoxicity and neuroinflammation, establishing a feed-forward cycle of KP dysregulation, 5-HT depletion, HPA axis hyperactivity, and increased vulnerability to MDD

HUVECs were incubated with p-cresol at 25 g/mL for 24 h, resulting in the generation of EMVs, which interfere with endothelial repair processes by decreasing the migratory capacity and the ability to form new vessels and by increasing cell senescence

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Lycopene-protein complex follows hepatic pathway to reach the target tissues (Gao et al., 2008

Sun L, Liu T, Liu J, Gao C, Zhang X