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Aggregation of these proteins and the subsequent reduction of FeS clusters, which are essential cofactors for various cellular processes, including electron transport and enzymatic reactions [102], promote proteotoxic stress and ultimately lead to cell death ( Fig

The immune-kynurenine pathway in social anxiety disorder

This process relies on the Smad signaling pathway and can be blocked by inhibiting the PI3K/AKT/HIF-1 pathway to disrupt TGF-1-induced metabolic reprogramming and EMT ( In vitro experiments further demonstrated that HIF-2 deficiency impedes microglial polarization toward the protumor M2-like phenotype and suppresses Treg migration ( Nrf2 is a key factor that regulates ferroptosis tolerance, and its abnormal activation is closely related to the survival, proliferation, and therapeutic resistance of tumor cells

(May 2020)

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