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This can impair astrocyte regulation of the tripartite synapse, BBB, and neuronal metabolism

Due to the formation of intramolecular hydrogen bonds between the -COO- group and -OH group in the ortho position in 2,3-DHBA, the 2,3- and 3,4-DHBA molecules behave somewhat differently in aqueous solution, which is reflected in their speciation behavior [1]

Originally designed as an intra-articular injection, it has also shown potent effects as a subcutaneous injection, and it is one of the only agents that has been shown to strengthen cartilage tissue by increasing cross-linking and polymerisation of the large molecules found in cartilage: (79) (80) (81) (82) (83) (84)