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As seen from Table 1, the deuterated analog (Example 2) of the invention displayed some stability over time with Ti 2 extended to 74.63 min

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Tirzepatide, originally approved for type 2 diabetes management, has proven effective in helping with weight loss by controlling appetite and reducing cravings

189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level