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Recently, an interesting study identified dihydroorotate dehydrogenase (DHODH) as a novel ferroptosis suppressor that functions as independent of the classical GPX4 signaling pathway and revealed the mitochondrial lipid peroxidation-dependent ferroptosis pathway [79]

Hyperhomocysteinemia induces insulin resistance in male SpragueDawley rats

*Correspondence: Olivier Tabary, [email protected] This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The damage caused by unchecked oxidative stress extends beyond the mitochondria to other vital cellular structures, particularly the peroxisomes and lipid membranes

Downie G, McRae N