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Saponins Saponins are one of the secondary metabolite groups in medicinal herbs, exhibiting immunomodulatory properties using a variety of mechanism

Maiti A, DiNardo C, Rausch C, Pemmaraju N, Garcia-Manero G, Ohanian M, Daver N, Issa G, Borthakur G , Ravandi F, Alvarado Y, Kadia T, Jabbour E, Short N, Montalban-Bravo G, Jain N, Kornblau S, Masarova L, Wierda W, Sasaki K, Takahashi K, Yilmaz M, Burger J, Estrov Z, Verstovsek S, Andreeff M, Bose P, Ferrajoli A, Thompson P, Montalbano K, Vaughan K, Bivins C, Pierce S, Qiao W, Ning J, Welch J, Kantarjian H, Konopleva M

Notably, proteins with the anti-senescent function were decreased in the maternal sub-anatomical region, while proteins associated with a switch from ATP to fatty acid consumption were increased in the middle and fetal sub-anatomical regions

[4] In contrast, methionine limitation in the diet decreased insulin resistance in rodents and promoted adipose tissue lipolysis and fatty acid oxidation

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