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Notably, 5-fluorouracil (5-FU), a key chemotherapeutic for CRC, also shows strong antimicrobial activity against Fusobacterium nucleatum (Fn), a bacterium linked to poor prognosis and chemoresistance (LaCourse et al., 2022)

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The pharmacokinetic data for all four PDE5Is and their associated adverse events are presented in Tables 5.3 and 5.4, respectively

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