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Interestingly these patterns of secretion are similar in both nocturnal (rodents) and diurnal (human) studies

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Step 1: ring opening The furanose ring of ribose 5-phosphate is opened by interaction with an aspartic acid residue (Asp 81 ), which accepts a proton from the hydroxyl group bound to C-1

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These differing findings may be attributed to variations in lactation stages across studies, the extension of analyses over longer periods, increased sample numbers and sampling frequency, population- and mother-specific dietary differences (particularly mineral supplementation), and inconsistencies in sample collection protocols