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Tetrahydrobiopterin in Energy Metabolism and Metabolic Diseases

The mean difference in the slope of decline between lead-in and 6 months after injection was also significantly lower in the treated group

For analysis of mRNA transcripts, cDNA was synthesized from one microgram of DNase Itreated total RNA using iScript cDNA synthesis Kit (Biorad)

Mitophagy inhibits macrophage activation and thus immune defense, resulting in decreased pathogen clearance and infection, while inhibition of mitophagy in macrophages can promote macrophage activation and thus inhibit infection