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This has nothing to do with b12 status and everything to do with excessive caloric deficit and insufficient protein intake relative to the rate of weight change

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NMDA and GABA Receptor Interactions Laboratory studies demonstrate DSIPs interaction with N-methyl-D-aspartate (NMDA) receptors, which play critical roles in learning, memory, and excitatory neurotransmission

Most growth factors degrade within minutes in this acidic environment

Simultaneously, glutathione-S-transferase (GST) activity decreases by 72%, reducing the cellular capacity to clear toxic metabolites ( 3.3 Oxidative stress and mitochondrial dysfunction EED-induced oxidative stress represents a central mechanism underlying reproductive toxicity, with mitochondrial dysfunction serving as both cause and consequence of excessive reactive oxygen species production