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Moreover, chronic or prolonged supplementation with ALA after the cessation of stress stimuli may not provide additional metabolic or anti-oxidative benefits, and in some cases, may partially associated with histopathological changes in liver or induce pro-oxidant effects under normal physiological conditions (5052)

Do not use in pets with hypersensitivity to hydroxocobalamin

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Those with active malignancy, certain pituitary issues, or poorly controlled diabetes may not be appropriate and require careful medical evaluation first