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Growth hormone secretagogues demonstrate a bell-shaped dose-response curve, meaning that beyond a certain threshold, increasing the dose yields no additional benefit and may reduce receptor sensitivity. Smith et al., Peptides Taking too much Ipamorelin can lead to diminished returns , or worse, GH resistance , where your body adapts and no longer responds

J Leukoc Biol 76:862867

Although the benefits from the weight loss and associated comorbidities are significant, surgical weight loss carries with it long term responsibilities

Caution should be exercised in patients with a history of heart disease, diabetes, hypertension, or kidney problems

Different peptides interact with different pathways in the body