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While collagen is a component of cartilage extracellular matrix, GHK-Cus effects appear more pronounced in skin and connective tissue rather than cartilage specifically

McElroy SL, Kotwal R, Hudson JI, Nelson EB, Keck PE

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Moreover, the BPC 157-activated bypassing key might act through modulatory effects on the prostaglandins system (i.e., counteracting non-steroidal anti-inflammatory drugs (NSAIDs) toxicity (for review, see i.e., [35]) and leaky gut syndrome (for review, see, i.e., [4]), acting also as a free radical scavenger [4,36,37,38]) and through modulatory effects on the nitric oxide (NO) system (i.e., interaction with NO agents in various models and species) [39], and in particular through special BPC 157/NO system relations (for review, see, i.e., [39])

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