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Nevertheless, these studies collectively highlight the vast potential of SQOR as a therapeutic targetranging from engineered microbes for environmental bioremediation to metabolic modulation and small-molecule drugs for disease interventionunderscoring the immense promise of SQOR-targeted strategies

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Second, several studies reported an association between elevated circulating homocysteine and mortality in patients with coronary heart disease independent of conventional risk factors (Alfthan et al, 1997