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This susceptibility stems from reduced basal GSH levels caused by impaired plasma membrane expression of SLC7A11

A randomized phase III trial evaluated selenium supplementation in selenium-deficient gynecological cancer patients receiving adjuvant radiotherapy, and it proved effective in reducing the incidence of grade 2 diarrhea, particularly in patients with a large planning target volume (387, 388)

Nevertheless, more evidence is needed in order to determine a clear role of GSTA1 and GSTM3 genes on cisplatin-based therapy