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Together these results establish 4HNE as the biological ligand for GDAP1, provide mechanistic insight into 4HNE binding, and demonstrate that altered 4HNE recognition is the likely mechanism underlying CMT-causing mutants such as T157P near the 4HNE binding site

Most of the compounds produced an anti-inflammatory response superior to the indomethacin control, reaching a concentration necessary for 50% inhibition of 0.45 g/ml for superoxide anion generation, and 1.68 g/ml for elastase release

If your primary concern is musculoskeletal (joint pain, tendon repair, muscle recovery), subcutaneous injections are the standard approach

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