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By "substantially homologous" is meant an amino acid sequence which is at least about 50% homologous to the amino acid sequence of PfEMPl or a biologically active fragment thereof, preferably at least about 90% homologous, and wore preferably at least about 95% homologous

2) and (2) the seven reported suppressor mutations from the yeast model of disease can be all mapped onto the hydrophobic face of the regulatory domain that forms the BatemanBateman interface (Fig

doi: 10.1371/journal.ppat.1005816 42 RompikuntalPKThayBKhanMKAlankoJPenttinenAMAsikainenSet al

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This frequency is considered a general guideline to start with