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7.4.1.2 Glial cell-derived neurotrophic factor (GDNF) GDNF is another neurotrophic factor that plays a key role in neuronal survival, particularly in dopaminergic neurons

At the same time, ROS-mediated pathways regulate immune cell priming in peripheral lymphoid organs

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Thus, it is conceivable that despite the initial adaptation of hepatic cells to compensate with enhanced GSH synthesis and antioxidant capacity the surge of ROS inherent to ethanol metabolism [81,83], mGSH levels cannot be fully restored because of ethanol-induced rise of mitochondrial cholesterol and the consequent reduced mGSH transport to the mitochondria [41]

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Linnewiel K., Ernst H., Caris-Veyrat C., Ben-Dor A., Kampf A., Salman H., Danilenko M., Levy J., Sharoni Y