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Activating the HGF/c-Met signaling pathway initiates a cascade of events that: Stimulates synaptogenesis the physical formation of new synaptic connections between neurons Promotes dendritic spine formation the small protrusions on neurons essential for receiving signals Enhances synaptic density in brain regions associated with learning and memory Supports neural stem cell activity and neuroplasticity Reduces neuroinflammatory signaling, offering a neuroprotective effect Structural vs

The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks

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Expert Rev Mol Diagn 18:165180 Wang Q, Zhang H, Xu H, Zhao Y, Li Z, Li J, Wang H, Zhuge D, Guo X, Xu H et al (2018b) Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair

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