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Compared with low doses (2h/4h, 200 mg/Kg) (101), high doses (2h/4h, 1300 mg/Kg) (102) of taurine were more effective, such as more indexes of I/R injury being improved (testicular histopathological damage and apoptosis)

In laboratory and experimental research settings, NNMT inhibition by 5-Amino-1MQ has been investigated for its potential interaction with: Intracellular NAD regulation SIRT1-related signaling pathways AMPK-related cellular-energy pathways Mitochondrial-related metabolic function Cellular-energy and metabolic-regulation pathways These pathways have contributed to growing research interest in 5-Amino-1MQ within metabolic-regulation and healthy-aging investigations

Curr Opin Toxicol 7:6066 Schopfer FJ, Baker PR, Freeman BA (2003) NO-dependent protein nitration: A cell signalling eventoran oxidative inflammatory response

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6d) and extended the lifespan almost twice as much (with only a slight delay in development, Supplementary Fig