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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Wadhwani S.A., Shedbalkar U.U., Singh R., Chopade B.A

Additionally, the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-FMK), the potent blood-brain barrier-penetrant necroptosis inhibitor necrostatin-1 (Nec1), and the selective ferroptosis inhibitor ferrostatin had no impact on the total number of viable cells and cytotoxicity (Supplementary Fig

10.1146/annurev.pharmtox.47.120505.105110 220 NadadurM.StanczykF

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In parallel, NF-B acts as the master switch for pro-inflammatory gene expression, and its hyperactivation drives the production of inflammatory mediators such as TNF- and IL-1[49-53]