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The metabolite of MPTP, MPP + , induces mitochondrial dysfunction, increases oxidative stress, and leads to neuronal death, exhibiting PD-like pathological characteristics 21

These changes skew microglial activation, upregulate inflammatory pathways (TLR9, NLRP3, cGASSTING), and alter gene expression in developing neurons

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Stress Management: Techniques like meditation, yoga, and regular exercise can reduce stress, which may contribute to dark circles

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